A rare but serious inflammatory condition that affects children who contract COVID-19 produces a distinctive pattern of biomarkers that may help doctors predict disease severity and also aid researchers in developing new treatments, according to a Cedars-Sinai-led study.
Los Angeles County’s latest coronavirus caseload update, meanwhile, was on hold Saturday evening as the Department of Public Health reported that it had experienced an error in its reporting system, which delayed release of the latest data. Officials hoped to post the numbers later that night.
According to the state dashboard, however, the county’s hospitalization numbers continued to flatten out, dropping from 1,708 on Friday to 1,692 on Saturday. Intensive care patients also ticked down a bit, from 451 to 436.
On Friday, 30 new fatalities lifted the county’s overall death toll from COVID-19 to 25,211. The county reported another 2,789 cases on Friday, giving the county a cumulative total from throughout the pandemic of 1,397,236.
The Cedars-Sinai study, released Friday, focused on multisystem inflammatory syndrome in children, an inflammatory response involving multiple organs that can occur weeks after infection with SARS-CoV-2, the virus that causes COVID-19. Although most patients improve with medical care, more than half the MIS-C cases in the U.S. require ICU admission, and the condition can be deadly.
As of Aug. 15, 4,404 MIS-C cases and 37 fatalities in the U.S. had been reported to the U.S. Centers for Disease Control and Prevention. The median age of MIS-C patients was 9 years, and more than 60% of the cases were in Black or Latinx children, according to the report.
“It is crucial to improve our understanding of MIS-C in the current environment, given reports of rising rates of children being hospitalized with COVID-19 in the U.S. and the return of many students to school for the fall term,” said Dr. Moshe Arditi, director of the Pediatric Infectious Diseases Division at Cedars-Sinai. “The disproportionate impact of MIS-C related to race and ethnicity is especially troubling.”
Arditi, a professor of pediatrics and the GUESS?/Fashion Industries Guild Chair in Community Child Health, is co-senior author of the study published in the peer-reviewed Journal of Clinical Investigation.
A picture is emerging of MIS-C as an autoimmune disease in which the immune system becomes overactive and mistakenly attacks the body’s own organs, Arditi explained. This process may be triggered by widespread tissue damage caused by the SARS-CoV-2 infection.
City News Service contributed to this report
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